Karisma Face, full name Karisma Rh Collagen Face, is injected into the dermis, the middle layer of the skin, by a doctor using a very fine needle or a cannula. The most common methods are small micro-papules placed across the treatment area, similar to mesotherapy, and retrograde linear threads along fine lines. The product comes in a 2 ml prefilled syringe, and a typical course includes two or more sessions spaced a few weeks apart. The goal is not to fill or reshape the face, but to distribute the product evenly so it can improve skin quality, elasticity and collagen production from within.

How is Karisma injected? Superficially and evenly, into the dermis, with small amounts at many points rather than large amounts in one place. The injection technique, depth and spacing are chosen by the doctor for each area and each patient. This article explains how the procedure works for patients who want to understand what happens during treatment. It is not a guide for self-injection: Karisma is a medical device that should only be injected by a trained doctor in a clinic.

What Is Karisma Rh Collagen?

Karisma Rh Collagen is made by the Italian company Taumedika. It is a soft, injectable formulation with three components:

• A recombinant human type I collagen alpha-1 chain, produced by transgenic silkworms, so it is not of animal origin
• Non-crosslinked high molecular weight hyaluronic acid, which supports hydration
• Carboxymethyl cellulose (CMC), which stabilises the formulation

Laboratory research on human fibroblasts has shown that the formulation increases type I collagen production, and a 2024 clinical study reported improvements in skin quality after two sessions. Because the collagen is recombinant and described as hypoallergenic, it carries a lower risk of allergic reactions than older animal-derived collagen fillers.

Why Injection Technique Matters with Karisma

Karisma is often called a soft filler or skin booster, but it does not work like a classic dermal filler. Hyaluronic acid fillers are placed deeper to create volume, lift and contour. Karisma works where collagen-producing fibroblasts live, in the dermis, and its job is to improve skin structure, elasticity and texture.

This changes the way it is injected. The doctor uses small amounts at many points to cover the whole area evenly, at a superficial depth, instead of placing a bolus to build volume. Correct depth and even distribution help achieve natural results and reduce the risk of visible lumps or irregularities.

How Karisma Is Injected: The Main Techniques

Micro-papules (mesotherapy technique)

The doctor places many tiny deposits of product just under the skin surface, in a grid across the treatment area. Each deposit leaves a small raised bump that flattens within hours. This method gives even coverage of larger areas such as the cheeks, and is the most typical way skin boosters are injected.

Retrograde linear threading

The needle is inserted along a fine line or a wrinkle, and the product is released slowly while the needle is withdrawn. This places a thin thread of Karisma directly under the line. It is often used for fine lines around the mouth, on the forehead or on the neck.

Cannula technique

Some doctors use a blunt cannula instead of a needle. Through one entry point, the cannula can distribute the product in a fan-shaped pattern across the area, with fewer punctures, which may mean less bruising.

Injection by Area

• Cheeks and mid-face: usually micro-papules or a cannula, to improve firmness, texture and elasticity across the whole area.
• Lower face and jawline: small, evenly spaced deposits to improve skin quality and early laxity; this is not jawline contouring with filler.
• Around the eyes: very careful, superficial technique because the skin is thin; used for crepey texture and fine lines, not for tear trough hollows.
• Around the mouth and lip lines: linear threading along fine lines.
• Neck and décolleté: micro-papules or linear threads along horizontal lines.
• Hands and body areas such as stretch marks or scars: chosen individually by the doctor.

The exact depth, spacing and amount per point vary with the skin, the area and the patient’s goals. This is why Karisma injection should always be planned by an experienced doctor.

What Happens During a Karisma Session

1. Consultation. The doctor reviews your medical history, allergies, medications such as blood thinners, and previous fillers or cosmetic treatments. They check whether your main concern is skin quality, which suits Karisma, or volume loss, which may need a different treatment.
2. Mapping. The doctor marks the treatment areas and plans how the 2 ml syringe will be distributed.
3. Preparation. The skin is cleansed and disinfected. A numbing cream may be applied for comfort, especially around the mouth and eyes.
4. Injection. Using micro-papules, linear threads or a cannula, the doctor injects small amounts evenly across each area.
5. Final check. The skin is gently cleaned, and the doctor reviews the result and gives aftercare instructions.

The injection itself usually takes 20 to 30 minutes, and the full appointment often under an hour.

Treatment Protocol: How Many Sessions?

Karisma is given as a course rather than a single injection. In the 2024 clinical study, patients received two sessions of 2 ml each, one month apart, with improvement measured at 30 and 60 days. In practice, your doctor sets the number of sessions and the interval based on your age, skin condition and goals, and may suggest maintenance sessions later to keep the results long-lasting.

Combining Karisma with Other Treatments

Karisma can be combined with Botox for muscle-driven wrinkles, hyaluronic acid fillers for volume, Sculptra or Radiesse for structural support, and microneedling, laser resurfacing, chemical peels or PRP for texture and acne scars. These are usually not done on the same day; the doctor plans the order so that each treatment works safely.

After the Injection: What to Expect

Right after treatment, the small papules from the injections are visible; they usually flatten within a few hours to a day. Mild redness, swelling, tenderness and small bruises are possible and settle within a few days. The visible improvement in skin texture, elasticity, hydration and fine lines builds gradually over the following weeks as collagen production increases.

Post-treatment care:

• Do not massage, rub or press the treated area unless your doctor tells you to.
• Avoid makeup for the rest of the day, and avoid intense exercise, saunas, steam rooms, swimming and heat for a day or two.
• Pause retinoids, strong acids, peels and other active skin care products until the skin settles.
• Use a broad-spectrum sunscreen daily; this is especially important in Dubai’s strong sun.
• Contact your clinic if swelling, pain or redness gets worse instead of better.

Who Should Inject Karisma?

Karisma should only be injected by a licensed doctor in a medical setting. Even superficial injections need knowledge of facial anatomy, sterile technique and the ability to recognise and manage complications. Buying Karisma online and injecting it at home is unsafe: the product may not be genuine or properly stored, and incorrect depth or technique can cause lumps, infection, scarring or other complications.

Karisma is usually avoided during pregnancy and breastfeeding, over active skin infections or inflamed acne in the area, and in patients with known allergies to its components.

Karisma Face Injection in Dubai

In Dubai, Karisma is offered by DHA-licensed dermatology and medical aesthetics clinics. One example is a DHA-licensed polyclinic in Umm Al Sheif where doctors use Karisma Rh Collagen for the cheeks, lower face, jawline area and selected areas around the eyes, choosing between micro-papule and linear injection techniques after a consultation that first checks whether the concern is skin quality or volume loss.

When choosing a clinic, check that the clinic and the doctor are licensed by the Dubai Health Authority (DHA), ask to see the genuine Karisma product and syringe, and make sure the doctor explains the injection technique, the number of sessions and the expected results. Correct technique is what turns Karisma into a safe, natural and effective skin rejuvenation treatment.